Prevalence of HLA-DQ2 and DQ8 haplotypes that predispose to celiac disease in Mexico
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چکیده
منابع مشابه
The likelihood ratio and frequency of DQ2/DQ8 haplotypes in Iranian patients with celiac disease
AIM The aim of this study was to evaluate the likelihood ratio and frequency of DQ2 and DQ8 in Iranian patients with celiac disease (CD). BACKGROUND The HLA DQ2 and HLA DQ8 are the important mediators in the development of celiac disease. A few studies evaluated the frequency of HLA DQ2 and HLA DQ8 haplotypes among the Iranian population with low sample size. PATIENTS AND METHODS In this cr...
متن کاملThe Prevalence of Hla Dq2 and Dq8 in Patients with Celiac Disease, in Family and in General Population
BACKGROUND Celiac disease is an enteropathy characterized by gluten sensitivity and broad clinical aspect. Has a multifactorial cause and depends on genetic, immunological and environmental factors for its development. The genetic influence is given mostly by the human leukocyte antigens HLA DQ2 and DQ8. AIM To evaluate the prevalence of human leukocyte antigens DQ2 and DQ8 in three different...
متن کاملHLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease.
Celiac disease is associated with HLA-DQ2 and, to a lesser extent, HLA-DQ8. Type 1 diabetes is associated with the same DQ molecules in the opposite order and with possible involvement of trans-encoded DQ heterodimers. T cells that are reactive with gluten peptides deamidated by transglutaminase 2 and invariably restricted by DQ2 or DQ8 can be isolated from celiac lesions. We used intestinal T ...
متن کاملFunction of DQ2 and DQ8 as HLA susceptibility molecules in celiac disease.
Celiac disease (CD) is a malabsorptive disorder of the small intestine. The disease is a unique model for studies of HLA-associated diseases since (a) the disease shows a stringent HLA association; (b) the disease-inducing agent (wheat gluten and related antigens from other cereals) is known; (c) activated, gluten-specific CD4 + T cells in the lamina propria of the small intestine most likely p...
متن کاملthe likelihood ratio and frequency of dq2- dq8 haplotypes in iranian patients with celiac disease
aim : the aim of this study was to evaluate the likelihood ratio and frequency of dq2 and dq8 in iranian patients with celiac disease (cd). background : the hla dq2 and hla dq8 are the important mediators in the development of celiac disease. a few studies evaluated the frequency of hla dq2 and hla dq8 haplotypes among the iranian population with low sample size. patients and methods : in this ...
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ژورنال
عنوان ژورنال: Revista de Gastroenterología de México (English Edition)
سال: 2019
ISSN: 2255-534X
DOI: 10.1016/j.rgmxen.2018.06.010